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Ground breaking for the 125,000 square foot New Science Building took place October 19, 2007. Construction has moved at an astounding, unrelenting pace. In December of 2009 the building will be turned over to the College. Beginning in January 2010 the new facility will house the Departments of Chemistry/ Biochemistry, the Lowcountry Hazards Center, South Carolina Space Grant Offices, a NASA lunar outreach and education office, an earth history museum, GIS and Remote Sensing laboratories, and geosciences laboratories and offices. Portions of the building will temporarily remain unfinished with plans developing to house the Biology Department. The New Science Building features a 150-seat auditorium, state-of-the-art research and teaching laboratories, gathering areas for faculty and student interaction, and a large green space that recall the walled gardens of Historic Charleston. The first classes will meet there on January 10, 2010.

The Rita Liddy Hollings Science Center was built in the 1970's and early 1980's to accommodate 5,000 students. Currently undergraduate and graduate enrollment at the College is approaching 11,000. The campus facilities plan includes the renovation and refurbishment of the Rita Liddy Hollings Center in the near future